Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets?
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists.
Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGCR); secondary non-genomic effects which are also ini...
متن کاملSelective glucocorticoid receptor modulators: future of glucocorticoid immunosuppressive therapy?
In 1950 Hench, Kendall, and Reichstein received the Nobel Prize in Medicine for the characterization and isolation of glucocorticoids and the subsequent discovery of their antiinflammatory properties. To date, glucocorticoids are still widelyprescribedandplayanimportantrole inthetreatment of a variety of clinical disorders, including inflammatory diseases, autoimmune disorders, and hematologica...
متن کاملSelective glucocorticoid receptor-activating adjuvant therapy in cancer treatments
Although adverse effects and glucocorticoid resistance cripple their chronic use, glucocorticoids form the mainstay therapy for acute and chronic inflammatory disorders, and play an important role in treatment protocols of both lymphoid malignancies and as adjuvant to stimulate therapy tolerability in various solid tumors. Glucocorticoid binding to their designate glucocorticoid receptor (GR), ...
متن کاملGlucocorticoid-receptor interactions. Discrimination between glucocorticoid agonists and antagonists by means of receptor-binding kinetics.
The kinetics of binding to the molybdate-stabilized glucocorticoid receptor of rat thymus cytosol were determined at 0 degrees C for a number of glucocorticoid agonists and antagonists. Equilibrium constants derived from the rate constants for association and dissociation were in good agreement with those determined directly or by competition under equilibrium conditions. Kinetics parameters fo...
متن کاملFrom receptor balance to rational glucocorticoid therapy.
Corticosteroids secreted as end product of the hypothalamic-pituitary-adrenal axis act like a double-edged sword in the brain. The hormones coordinate appraisal processes and decision making during the initial phase of a stressful experience and promote subsequently cognitive performance underlying the management of stress adaptation. This action exerted by the steroids on the initiation and te...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2012
ISSN: 0884-0431
DOI: 10.1002/jbmr.1753